Skip to Content
Translational Research Program (TRP)
Last Updated: 07/22/16

Kidney SPOREs

It is estimated that there will be over 65,000 new cases of cancers of the kidney and renal pelvis in 2013 and about 13,000 deaths. The SPORE in renal cancer, which began in 2001, is a highly integrated program focusing on tumor genetics, minimally invasive therapy, and immune immunotherapy for renal cell carcinoma. This SPORE approaches the therapeutic intervention of this disease from several different angles, including angiogenesis inhibition, immune modulation, and inhibition of specific cancer-related molecular pathways. A notable accomplishment of this SPORE is its identification of a gene whose inactivation accounts for approximately one-third of Wilms tumors, a common pediatric tumor.

The renal SPORE fosters collaborations among the national experts in renal cancer, and generates resources and research opportunities which otherwise would not exist for the scientific community. The leadership of the Renal SPORE engages experts from throughout the United States and abroad through the Kidney Cancer Association, Society for Biological Therapy, the Cytokine Working Group or through collaborations in industry-sponsored trials. The SPORE offers its expertise and facility as a resource for correlative biomarkers for a number of nationally conducted clinical trials and also conducts national meetings on topics focused on different aspects of translational research in kidney cancer.

Dana-Farber Harvard Cancer Institute

David F. McDermott, M.D. [Click Here]
Beth Israel Deaconess Cancer Center/Dana-Farber/Harvard Cancer Center
Director, Biologic Therapy and Cutaneous Oncology Program
Division of Hematology/Oncology
375 Longwood Ave.
Masco Building, Room 412
Boston, MA 02215
Tel: 617-632-9250
Fax: 617-632-9260

William G. Kaelin, Jr., M.D.
Professor of Medicine
Dana-Farber Cancer Institute and Harvard Medical School
Howard Hughes Medical Institute
450 Brookline Avenue, Mayer 457
Boston, MA 02215 USA
Tel: 617-632-3975
Fax: 617-632-4760

For more information on this specific SPORE’s institution, please visit:

University of Texas Southwestern

James Brugarolas, M.D., Ph.D. [Click Here]
Associate Professor
Department of Internal Medicine, Oncology Division
Department of Developmental Biology
University of Texas Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9133
Tel: 214-648-4059
Fax: 214-648-1960