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Translational Research Program (TRP)
Last Updated: 09/14/15

Cervical SPOREs

Gynecological (GYN) cancer SPOREs focus on translational research in cervical and endometrial cancers. In 2013, the program supported two GYN SPOREs: one in cervical and one in endometrial cancer.

Cervical cancer development is driven by the transforming abilities of the human papillomavirus (HPV), while the etiology of endometrial cancer is associated with hormonal and other metabolic disorders such as obesity and diabetes. Although the incidence of cervical cancer is fairly low in the United States due to the advent of the "pap" smear test (12,340 new cases and 4,030 deaths are projected in 2013 by the American Cancer Society), it is a major health threat in the Third World and developing countries, with the overall worldwide incidence approaching 400,000 cases per year. Major activities within the JHU Cervical SPORE include developing better interventions for prevention, and therapy. The JHU Cervical SPORE is developing next generation of preventive and therapeutic vaccines against human papilloma virus.

Endometrial cancer is expected to be diagnosed in 49,560 women in the United States in 2013 and result in 8,190 deaths. The current MDACC Endometrial Cancer SPOREs is studying the effects of obesity and insulin resistance on the development of endometrial cancer, testing novel treatment and preventative agents, and developing predictive/prognostic biomarkers. Annual symposium organized by the MDACC Endometrial SPOREs reaches out to investigators within the United States and abroad to help support and unify translational activities within this cancer site.

Johns Hopkins University

T.C. Wu, MD, PhD [Click Here]
Departments of Pathology, Oncology,
Obstetrics and Gynecology and
Molecular Microbiology and Immunology
Johns Hopkins University
School of Medicine
Department of Pathology
1550 Orleans Street, CRB II Room 309
Baltimore, MD 21231
Tel: (410) 614-3899
Fax: (443) 287-4295

For more information on this specific SPORE’s institution, please visit:

University of Texas/MD Anderson

Karen H. Lu, MD [Click Here]
Professor and Chair
Department of Gynecologic Oncology
University of Texas
MD Anderson Cancer Center
1515 Holcombe Boulevard, Unit 1362
Houston, TX 77030
Tel: (713) 745-8902
Fax: (713) 792-7586

For more information on this specific SPORE’s institution, please visit: