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U.S. National Institutes of Health
Last Updated: 11/28/13


Skin cancer is the most common form of cancer in the United States. The three major types of skin cancer are the highly curable basal cell carcinoma, squamous cell carcinomas and the more serious malignant melanoma. Exposure to the sun's ultraviolet (UV) rays appears to be the most important environmental factor involved in the development of skin cancer. Individuals at high risk for melanoma have also been identified, some of whom have been found to carry mutations in several cancer related genes. Over 82,770 individuals in the United States will be diagnosed with "malignant" skin cancer in 2013 (excluding basal and squamous cell carcinoma) and 12,650 individuals will die of this disease. The skin SPOREs are focused predominantly on melanoma research activities, but also include projects focused on the treatment of cutaneous T-cell lymphoma (CTCL). The translational activities for melanoma include the development of novel immunotherapeutics, characterization of risk and prognostic biomarkers, as well as the use of novel animal and cell culture models to test therapeutic or preventative agents.

Brigham and Women’s Hospital

Thomas S. Kupper, MD [Click Here]
Chairman, Department of Dermatology
Brigham and Women’s Hospital
Harvard Institutes of Medicine
77 Louis Pasteur Avenue
Boston, MA 02115
Tel: (617) 525-5550
Fax: (617) 525-5571

For more information on this specific SPORE’s institution, please visit:

H. Lee Moffitt Cancer Center

Jeffrey S. Weber, M.D., PhD
Senior Member
H. Lee Moffit Cancer Center
12902 Magnolia Drive, SRB-2
Tampa, FL 33612
Phone: (813) 745-2691
Fax: (813) 449-8260

University of Pittsburgh

John M. Kirkwood, MD [Click Here]
Usher Professor of Medicine and Dermatology
Vice Chairman/Clinical Research, Dept. of Medicine
Director, Melanoma and Skin Cancer Program
University of Pittsburgh Cancer Institute
Department of Medicine
5117 Centre Avenue
Hillman Cancer Center, Room 1.32
Pittsburgh, PA 15213
Tel: (412) 623-7707
Fax: (412) 623-7704

University of Texas/MD Anderson

Elizabeth A. Grimm, PhD [Click Here]
Co-Director, Melanoma Research Program
Professor, Department of Bioimmunotherapy, Unit 362
University of Texas
M.D. Anderson Cancer Center
Department of Experimental Therapeutics
1515 Holocombe Boulevard, Box 362
Houston, TX 77030
Tel: (713) 792-3667
Fax: (713) 792-2070

Yale University

Ruth Halaban, PhD [Click Here]
Senior Research Scientist
Yale University School of Medicine
Department of Dermatology
PO Box 208059
HRT 610/LCI 500
New Haven, CT 06520
Tel: (203) 785-4352
Fax: (203) 785-7637