Sarcomas represent a heterogeneous group of cancers that may stem from soft tissue (muscles, fat tissue), bone, cartilage, peripheral nerve sheets, or from other connective tissues. Many of these tumors affect children and young adults accounting for 15% of all pediatric cancers. The incidence for individual sarcoma types is rather low and all combined amount to approximately 13,000 new cases per year (American Cancer Society data for 2011). The estimated death rate for 2011 is about 4,500 patients. The first and only Sarcoma SPORE so far was awarded in 2010.