Sarcomas represent a heterogeneous group of cancers that may stem from soft tissue (muscles, fat tissue), bone, cartilage, peripheral nerve sheets, or from other connective tissues. Many of these tumors affect children and young adults accounting for 15% of all pediatric cancers. The incidence for individual sarcoma types is rather low and all combined amount to approximately 14,420 new cases per year (American Cancer Society data for 2013). The estimated death rate for 2013 is about 5,830 patients. The first Sarcoma SPORE was awarded in 2010 the second in 2012.