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U.S. National Institutes of Health
Last Updated: 11/28/13

Brain SPOREs

It is estimated that in 2013 there will be 23,130 new cases of cancer of the brain and nervous system and 14,080 deaths in the United States. Conventional cytotoxic agents have provided little benefit for brain cancer patients and brain cancer incidence, morbidity and mortality have not changed significantly in 20 years. The Brain Cancer SPORE program was initiated in 2002. In 2013 the five (or 4 if you don’t count UAB?) brain SPORE teams are making significant progress in the development of unique approaches to diagnosis and treatment including exploring chromosomal and genetic variants associated with overall survival as well as predictive and prognostic markers. Non-invasive brain imaging studies are being developed for diagnostic utility and discovery of biomarkers of malignant transformation. Translational projects are targeting signaling pathways such as IDH, PI3K, p53, apoptosis and BRAFV600E (for pediatric brain cancers) as well as exploring the tumor microenvironment and inhibition of angiogenesis to understand the disease processes and develop clinical treatments. Various SPORE teams are finding preliminary promising results using genetically engineered oncolytic measles, adenoviral and herpes simplex viruses and reversing immune suppression in immunotherapy strategies. This highly collaborative group works together to share ideas, results, resources, and clinical populations.

Massachusetts General Hospital

Tracy T. Batchelor, M.D., MPH [Click Here]
Professor
Center for Neuro-Oncology
Mailstop: Yawkey Center 9E
Massachusetts General Hospital
55 Fruit Street
Boston, MA 02114
Phone: (617) 724-8770
Fax: (617) 724-8769
Email: tbatchelor@partners.org

Mayo Clinic, Rochester

Brian Patrick O'Neill, MD [Click Here]
Mayo Clinic Rochester
Mayo Clinic Cancer Center
200 First Street Southwest
Rochester, MN 55905
Tel: (507) 538-7275
Fax: (507) 284-4074
Email: boneill@mayo.edu

For more information on this specific SPORE’s institution, please visit:
http://cancercenter.mayo.edu/mayo/research/neurooncology_program/spore_brain.cfm and Mayo Clinic SPORE in Brain Cancer (PDF)

University of California, San Francisco

Mitchel S. Berger, MD [Click Here]
University of California, San Francisco
Department of Neurological Surgery
505 Parnassus Avenue, Room M-786
San Francisco, California 94143
Tel: (415) 353-3933
Fax: (415) 353-3910
Email: bergerm@neurosurg.ucsf.edu

For more information on this specific SPORE’s institution, please visit:
http://neurosurgery.medschool.ucsf.edu/neurosurgery_research/btrc/index.html

University of Texas/MD Anderson

Frederick F. Lang, Jr., M.D., F.A.C.S., F.A.A.N.S. [Click Here]
Professor
Department of Neurosurgery
1400 Holcombe Blvd, Unit 442
Houston, TX 77030
Phone: (713) 792-2400
Fax: (713) 794-4950
Email: flang@mdanderson.org

For more information on this specific SPORE’s institution, please visit:
http://www.mdanderson.org/education-and-research/research-at-md-anderson/early-detection-and-treatment/research-programs/spores/brain-cancer-spore/index.html